The building that today shelters the Museum of Coffe, La Casona as it is known, has a history of its own; the building was built on 1913 as a home for the doctor Rafael Grajales Ramos, the owner, who lived there until 1933. On 1943, the doctor Grajales Ramos donates the building to the Government of the State, so the Museum of Archeology and History could be installed there. On 1942, it became the Regional Museum of Chiapas. The building is registered in the National Catalogue of Monument Buildings of the State of Chiapas, by the National Institute of Anthropology and History.

The Museum of Coffee opened its doors on August 1st, 2009, with the objective of professionalize an instrument of promotion that would allow, in a permanent way, the encouragement of the recovery of coffee culture in the entity, and, therefore, to stimulate the consumption of coffee from Chiapas, as well as to promote the entrepreneurial capacity of this productive chain, and to stimulate the production and consumption of products with high levels of social responsibility, to the environment and respect for the capacity of growth and social development of the coffee growers. In this way, the Museum of Coffee is an instrument for promotion, training, and the spreading of information about the social, economic, historical, and cultural importance of the production and consumption of coffee in Chiapas.