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The old San Pedro and San Pablo Hospital has an origin related to the construction of the temple of San Pedro founded in 1541, at the request of the Bishop of Tlaxcala based in Puebla, Fray Julian Garces. It was consolidated with Bishop Juan de Palafox y Mendoza sponsorship in 1647. During Ignacio Domenech’s administration, towards the end of the 19th century, San Pedro lived one of the most important stages of its history. Under its governance the development of medicine was encouraged and hospital conditions and good care to patients were improved.