In 1997, Roy Hargrove, a great American jazz trumpeer gave him his first trumpet and Yasek Manzano began to play in several sessions in the city. He returned to Havana in 2003 permeated with much more talent and energy, he formed his group and recorded his first album in collaboration with Roberto Martínez.

He has shared stages with important Cuban and foreign musicians, such as Bobby Carcassés, his first teacher; Chucho Valdés, Orlando Valle "Maraca", Celia Cruz, Los Van Van Orchestra, Irakere group and the American trumpeters Roy Hargrove and Nicholas Payton, among others.